Dietary phosphate disturbs of gut microbiome in mice

Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake dietary deteriorates and various complications including cardiovascular infectious diseases. Recent reports have demonstrated that gut microbiome disturbance associated with both the etiology progression disease. However, relationship between remains unknown. Here, we examined effects excessive on microbiome. Five-week-old male C57BL/6J mice were fed either control diet or high for eight weeks. Analysis microbiota was carried out using MiSeq next generation sequencer, short-chain fatty acids determined GC-MS. In analysis microbiota, significantly increased Erysipelotrichaceae decreased Ruminococcaceae observed group. Furthermore, induced reduction microbial diversity mRNA levels colonic tight junction markers. These results suggest disturbs affects intestinal barrier function.